Reported in PLOS ONE, this cell-sorting method consistently selects the highest quality, standardized iPS cells, representing a major step forward for the development of cell therapies. Employing a breakthrough method developed by 2012 Nobel laureate Shinya Yamanaka, adult cells are “reprogrammed” to an embryonic-like state, commonly through viral infection. Reprogramming results in a mixture of fully reprogrammed iPS cells, partially reprogrammed cells, and residual adult cells. Previously selecting promising fully reprogrammed cells was done by eye through a microscope.
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