Clinical trials

Clinical trials

New treatments for spinal cord injury are developed in the laboratory and at this stage are referred to as “preclinical”. They are usually tested using computer simulations or animal models, but promising preclinical treatments may not work as well in humans. So, the next stage is a “clinical” experiment.

Clinical trials are research studies using human subjects in order to test new treatments or interventions. They are the main way researchers find out if a new treatment, like a new drug or medical device, is safe and effective for people and if it is better than the treatments that are already available.

For spinal cord injuries these might involve such things as experimental drugs, stem cells and other cell types, biomaterials, medical devices, surgical and other medical procedures, rehabilitation methods and exercise, dietary changes,  or any combination of these.

SCI Clinical Trials
Australia 2022

This list is far from comprehensive but covers the main “cure-related” trials. If you are a researcher and would like your trial listed here, please email [email protected]

eWalk

Team lead: Profs Simon Gandevia and Jane Butler
Institution: Neuroscience Research Australia (NeuRA)
Intervention: Transcutaneous (non-invasive) neurostimulation
Primary target: Standing/walking
Eligibility:

  • Incomplete paras
  • Can take a step with or without assistance but can’t walk >10m
  • Motor level T2–T11-1 year post injury

Duration: 12 weeks, 3 visits/week
Enrolling: now  Sydney & Melbourne
More info:  [email protected]  https://www.neura.edu.au/research-centre/spinalcordresearchinjurycentre/
Register interest: https://data.neura.edu.au/surveys/?s=MR8YW7K7D3

 

Project Spark - community study 1

Team lead: Profs Simon Gandevia and Jane Butler
Institution: Neuroscience Research Australia (NeuRA) and NeuroMoves
Intervention: Transcutaneous (non-invasive) neurostimulation
Primary targets: Arm, hands, respiration
Eligibility: Quadriplegics (Exact details TBC)
Enrolling: Sydney, late 2022 - Perth, Q2/3 2023 - TBC, Late 2023
More info: Details once known and calls for volunteers will be published on SpinalCure’s newsletter, website and social media channels.

TESCoN

Team lead: Prof Mary Galea (in collaboration with Prof Reggie Edgerton)
Institution: University of Melbourne
Intervention: Transcutaneous (non-invasive) neurostimulation
Primary targets: Arm, hands
Eligibility: 

  • Quads below C4 (traumatic SCI)
  • Time since injury 3-6 months, or over 12 months
  • Aged between 18 and 60 years
  • Study duration: 5 days/week for 4 weeks

Enrolling:  Now - Royal Talbot Rehab Centre, Melbourne
More info: Please see this pdf.  Or contact Dr Maya Panisset, [email protected]

The RESTORE Trial

Team lead: Prof Sylvia Gustin
Institution: NeuRA and UNSW
Intervention: Immersive virtual reality
Primary targets:

  • Touch sensation
  • “Dis-complete” SCI (AIS A)

Details TBC
Enrolling: Soon,  UNSW Sydney
More info: https://www.neurorecoveryresearch.com/the-restore-trial

VR Walk

Team lead: Prof Sylvia Gustin
Institution: NeuRA and UNSW
Intervention: Immersive virtual reality
Primary targets: Pain
Eligibility: 

  • Lumbar paraplegic & quadriplegics C5–C7
  • AISA A
  • Home based

Enrolling: Now, UNSW Sydney
More info: https://www.neurorecoveryresearch.com/vrwalk-trial

Therapeutic AIH

Team lead: Prof Jane Butler
Institution: NeuRA, Sydney
Intervention: Acute Intermittent Hypoxia
Primary targets: Movement and breathing
Eligibility: 

  • Injury above T12
  • Incomplete
  • No implants

Study duration: 2, 3 or 5 weeks, 1 full day/week
Enrolling: Now, NeuRA, Sydney
More info: [email protected]
Register interest: https://data.neura.edu.au/surveys/?s=MR8YW7K7D3

SCAN Study

Team lead: Prof Luke Henderson
Institution: NeuRA, and University of Sydney
Intervention: Cannabidiol (CBD—cannabis extract)
Primary targets: Pain
Eligibility: 

  • Are over 18 years
  • Have a spinal cord injury
  • Do have ongoing neuropathic or nerve pain
  • Are willing to provide a small blood sample
  • Are willing to be exposed to brief painful stimulus
  • Are willing to attend the NeuRA facility to undergo an MRI and EEG

Enrolling: Now, USyd and NeuRA
More info: [email protected]
Register Interest: https://redcap.sydney.edu.au/surveys/?s=3PDYK79LCPXLNTRY

More effective rehab: robotics and gaming

Team lead: Dr Camila Quel De Oliveira, UTS
Institution: UTS
Intervention: robotics assisted gaming
Primary target: Upper limb, hands
Eligibility: Quadriplegics
Enrolling: Now, UTS, Sydney
More info: https://www.spinalcure.org.au/news/spinalcure-australia-funds-robotic-assisted-game-based-rehabilitation-program-for-people-with-spinal-cord-injury/
Contact: [email protected]

To find out about other SCI related trials currently in progress world-wide please visit scitrials.org

Details of all registered clinical trials can be found at clinicaltrials.gov and australianclinicaltrials.gov.au

Follow SpinalCure on Facebook or Instagram to get updates on trials funded by SpinalCure Australia.

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