{"id":4172,"date":"2015-04-23T15:56:40","date_gmt":"2015-04-23T05:56:40","guid":{"rendered":"http:\/\/www.spinalcure.org.au\/?p=4172"},"modified":"2015-04-23T15:56:40","modified_gmt":"2015-04-23T05:56:40","slug":"exciting-discovery-could-lead-to-new-treatments-for-acute-sci","status":"publish","type":"post","link":"https:\/\/www.spinalcure.org.au\/news\/exciting-discovery-could-lead-to-new-treatments-for-acute-sci\/","title":{"rendered":"\u201cExciting discovery\u201d could lead to new treatments for acute SCI"},"content":{"rendered":"

Rapid treatment with a new anti-inflammatory could have a major impact on recovery from spinal cord injury, University of Queensland<\/a> researchers have found.<\/p>\n

\"Inflammation
Inflammation after spinal cord injury.
Image source: Ms Faith Brennan and Mr Luke Hammond).<\/figcaption><\/figure>\n

UQ School of Biomedical Sciences\u2019 Dr Marc Ruitenberg and PhD student Ms Faith Brennan said they made the discovery during laboratory trials with an experimental drug.<\/p>\n

Ms Brennan said that excessive inflammation caused additional damage in spinal cord injuries and hindered recovery.<\/p>\n

\u201cWe found that a molecule called C5aR exacerbates inflammation and tissue damage after spinal cord injury,\u201d she said.<\/p>\n

\u201cOur study shows that drugs inhibiting C5aR can improve recovery when administered early after injury.<\/p>\n

\u201cThis exciting discovery could form the basis for new frontline therapies to treat patients with spinal cord trauma.\u201d<\/p>\n

Dr Ruitenberg said there was a critical time window for this new treatment.<\/p>\n

\u201cWhat we also discovered is that this molecule, C5aR, has multiple roles and is also needed for repair processes undertaken by astrocytes, a specialised type of cell in the spinal cord,\u201d he said.<\/p>\n

\u201cAstrocytes normally multiply in response to injury, which is an essential process to form a barrier between damaged and healthy tissue.<\/p>\n

\u201cAny long-term interference with this process could therefore make things worse.<\/p>\n

\u201cOur challenge was to find out how long treatment with the new drug could be continued before its beneficial effects were lost, and also to understand why this occurred so that adverse side-effects could be prevented.\u201d<\/p>\n

SpinalCure Australia CEO Mr Duncan Wallace, whose organisation supports the UQ research, said the study was a great step towards developing an effective treatment for spinal cord injury.<\/p>\n

\u201cIt takes us closer to the day when a spinal cord injury is no longer a life sentence,\u201d he said.<\/p>\n

The research is published on the cover of The Journal of Neuroscience<\/a> (The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury).<\/p>\n

Media: Lynda Flower, SBMS Marketing, +61 7 3365 1536 l.flower@uq.edu.au<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Rapid treatment with a new anti-inflammatory could have a major impact on recovery from spinal cord injury, University of Queensland<\/a> researchers have found.<\/p>\n

Continue reading “\u201cExciting discovery\u201d could lead to new treatments for acute SCI”<\/span>…<\/a><\/div>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22,26,28],"tags":[],"acf":[],"yoast_head":"\n\u201cExciting discovery\u201d could lead to new treatments for acute SCI - SpinalCure Australia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.spinalcure.org.au\/news\/exciting-discovery-could-lead-to-new-treatments-for-acute-sci\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u201cExciting discovery\u201d could lead to new treatments for acute SCI - SpinalCure Australia\" \/>\n<meta property=\"og:description\" content=\"Rapid treatment with a new anti-inflammatory could have a major impact on recovery from spinal cord injury, University of Queensland researchers have found.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.spinalcure.org.au\/news\/exciting-discovery-could-lead-to-new-treatments-for-acute-sci\/\" \/>\n<meta property=\"og:site_name\" content=\"SpinalCure Australia\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/spinalcure\" \/>\n<meta property=\"article:published_time\" content=\"2015-04-23T05:56:40+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.spinalcure.org.au\/wp-content\/uploads\/UQ-spinalcord.jpgitok8Jg9RzIs-300x300.jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@SpinalCure\" \/>\n<meta name=\"twitter:site\" content=\"@SpinalCure\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.spinalcure.org.au\/news\/exciting-discovery-could-lead-to-new-treatments-for-acute-sci\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.spinalcure.org.au\/news\/exciting-discovery-could-lead-to-new-treatments-for-acute-sci\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/www.spinalcure.org.au\/#\/schema\/person\/bc494ede8cba2d25b3ab64a0b6c126ed\"},\"headline\":\"\u201cExciting discovery\u201d could lead to new treatments for acute SCI\",\"datePublished\":\"2015-04-23T05:56:40+00:00\",\"dateModified\":\"2015-04-23T05:56:40+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.spinalcure.org.au\/news\/exciting-discovery-could-lead-to-new-treatments-for-acute-sci\/\"},\"wordCount\":348,\"publisher\":{\"@id\":\"https:\/\/www.spinalcure.org.au\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.spinalcure.org.au\/news\/exciting-discovery-could-lead-to-new-treatments-for-acute-sci\/#primaryimage\"},\"thumbnailUrl\":\"http:\/\/www.spinalcure.org.au\/wp-content\/uploads\/UQ-spinalcord.jpgitok8Jg9RzIs-300x300.jpeg\",\"articleSection\":[\"News\",\"Research\",\"Media releases\"],\"inLanguage\":\"en-AU\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.spinalcure.org.au\/news\/exciting-discovery-could-lead-to-new-treatments-for-acute-sci\/\",\"url\":\"https:\/\/www.spinalcure.org.au\/news\/exciting-discovery-could-lead-to-new-treatments-for-acute-sci\/\",\"name\":\"\u201cExciting discovery\u201d could lead to new treatments for acute SCI - 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